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M94A2774.TXT
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1994-10-25
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Document 2774
DOCN M94A2774
TI Studies on the HIV-specific IGA antibodies in sera and saliva.
DT 9412
AU Yasuda S; Iwasaki M; Honda M; Oka S; Takemori T; Tsunetsugu-Yokota Y;
Dept. of Immunol., AIDS RC, National Institute of Health, Tokyo,; Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):228 (abstract no. PB0342). Unique
Identifier : AIDSLINE ICA10/94369801
AB OBJECTIVE: To evaluate the diagnostic value of the detection of IgA type
anti-HIV antibodies, especially in infants born to HIV-infected mothers.
METHODS: Using anti-human IgA monoclonal antibody (22C) and purified p24
antigen, ELISA system was developed. Sera and saliva were obtained from
71 HIV-infected individuals of AC, ARC, and AIDS. Anti-p24 antibodies in
sera of 4 families with HIV infection were also studied. RESULTS: 1. The
titer of anti-p24 IgA as well as IgG antibodies decreases with
progression of the disease. 2. In saliva samples the detection of
anti-p24 IgA antibody appeared to be more sensitive than that of
anti-p24 IgG antibody. 3. Anti-p24 IgA antibodies in sera of infants
with HIV infection were significantly high, comparing to that of normal
infants. DISCUSSION AND CONCLUSIONS: Detection of HIV-specific IgA
antibodies has diagnostic value of HIV infection especially in infants
born to HIV-infected mother.
DE Comparative Study Evaluation Studies Female Human HIV
Antibodies/*ANALYSIS/BLOOD/IMMUNOLOGY HIV Core Protein p24/IMMUNOLOGY
HIV Infections/CONGENITAL/*DIAGNOSIS HIV-1/*IMMUNOLOGY
IgA/*ANALYSIS/BLOOD/IMMUNOLOGY IgG/ANALYSIS Infant, Newborn Pregnancy
Pregnancy Complications, Infectious Saliva/*IMMUNOLOGY Salivary
Proteins/*ANALYSIS Sensitivity and Specificity MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).